Age-Related Changes in Serum N-Glycome in Men and Women-Clusters Associated with Comorbidity.

ABSTRACT: (1) Aim: To describe, in a general adult population, the serum N-glycome in relation to age in men and women, and investigate the association of N-glycome patterns with age-related comorbidity; (2) Methods: The serum N-glycome was studied by hydrophilic interaction chromatography with ultra-performance liquid chromatography in 1516 randomly selected adults (55.3% women; age range 18-91 years). Covariates included lifestyle factors, metabolic disorders, inflammatory markers, and an index of comorbidity. Principal component analysis was used to define clusters of individuals based on the 46 glycan peaks obtained in chromatograms; (3) Results: The serum N-glycome changed with ageing, with significant differences between men and women, both in individual N-gl

SUBMITTER: Lado-Baleato O 

PROVIDER: S-EPMC10813383 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature