A Genetic Circuit Design for Targeted Viral RNA Degradation.

ABSTRACT: Advances in synthetic biology have led to the design of biological parts that can be assembled in different ways to perform specific functions. For example, genetic circuits can be designed to execute specific therapeutic functions, including gene therapy or targeted detection and the destruction of invading viruses. Viral infections are difficult to manage through drug treatment. Due to their high mutation rates and their ability to hijack the host's ribosomes to make viral proteins, very few therapeutic options are available. One approach to addressing this problem is to disrupt the process of converting viral RNA into proteins, thereby disrupting the mechanism for assembling new viral particles that could infect other cells. This can be done by ensuring precise control over the abundanc

SUBMITTER: Bello AJ 

PROVIDER: S-EPMC10813695 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature