Ontology highlight
ABSTRACT:
SUBMITTER: Estrada DF
PROVIDER: S-EPMC10813703 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Estrada D Fernando DF Kumar Amit A Campomizzi Christopher S CS Jay Natalie N
Methods in molecular biology (Clifton, N.J.) 20210101
The complex enzyme kinetics displayed by drug-metabolizing cytochrome P450 enzymes (CYPs) (see Chapter 9 ) can, in part, be explained by an examination of their crystallographic protein structures. Fortunately, despite low sequence similarity between different families of drug-metabolizing CYPs, there exists a high degree of structural homology within the superfamily. This similarity in the protein fold allows for a direct comparison of the structural features of CYPs that contribute toward diff ...[more]