Leveraging Biomaterial Platforms to Study Aging-Related Neural and Muscular Degeneration.

ABSTRACT: Aging is a complex multifactorial process that results in tissue function impairment across the whole organism. One of the common consequences of this process is the loss of muscle mass and the associated decline in muscle function, known as sarcopenia. Aging also presents with an increased risk of developing other pathological conditions such as neurodegeneration. Muscular and neuronal degeneration cause mobility issues and cognitive impairment, hence having a major impact on the quality of life of the older population. The development of novel therapies that can ameliorate the effects of aging is currently hindered by our limited knowledge of the underlying mechanisms and the use of models that fail to recapitulate the structure and composition of the cell microenvironment. The emergence

SUBMITTER: Hidalgo-Alvarez V 

PROVIDER: S-EPMC10813704 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature