Preliminary Study of the Relationship between Osteopontin and Relapsed Hodgkin's Lymphoma.

ABSTRACT: The primary objective of this study was to investigate the potential role of tissue osteopontin, also known as secreted phosphoprotein 1 (SPP1), as a contributing factor to an unfavorable prognosis in classical Hodgkin's lymphoma (HL) patients who received the same treatment protocol. The study involved 44 patients aged 4-22 years, with a median follow-up period of 3 years. Patients with higher levels of SPP1 were associated with tissue necrosis and inflammation, and there was a trend toward a poorer prognosis in this group. Before therapy, we found a correlation between positron emission tomography (PET) scans and logarithmic SPP1 levels (p = 0.035). However, the addition of SPP1 levels did not significantly enhance the predictive capacity of PET scans f

SUBMITTER: De Re V 

PROVIDER: S-EPMC10813762 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature