Toward Precision Medicine: Exploring the Landscape of Biomarkers in Acute Kidney Injury.

ABSTRACT: Acute kidney injury (AKI) remains a complex challenge with diverse underlying pathological mechanisms and etiologies. Current detection methods predominantly rely on serum creatinine, which exhibits substantial limitations in specificity and poses the issue of late-stage detection of kidney injury. In this review, we propose an up-to-date and comprehensive summary of advancements that identified novel biomarker candidates in blood and urine and ideal criteria for AKI biomarkers such as renal injury specificity, mechanistic insight, prognostic capacity, and affordability. Recently identified biomarkers not only indicate injury location but also offer valuable insights into a range of pathological processes, encompassing reduced glomerular filtration rate, tubular function, inflammation, and

SUBMITTER: Nourie N 

PROVIDER: S-EPMC10813773 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature