Inflammation and Fibrosis in Sleep-Disordered Breathing after Acute Myocardial Infarction.

ABSTRACT:

Background

After acute myocardial infarction (AMI), inflammatory processes promote tissue remodeling at the infarct site. Procollagen III amino-terminal propeptide (PIIINP) is a circulating biomarker of type III collagen synthesis that has been shown to be associated with changes in left ventricular ejection fraction (LVEF) and predicts the occurrence of heart failure after AMI. We hypothesize that sleep-disordered breathing (SDB) promotes inflammation and myocardial fibrosis, leading to reduced myocardial salvage. Therefore, in patients with first-time AMI successfully treated with percutaneous coronary intervention (PCI), we aimed to investigate whether circulating levels of high-sensitivity C-reactive protein (hs-CRP) and PIIINP are elevated in patients with SDB compared to pati

SUBMITTER: Pec J 

PROVIDER: S-EPMC10813793 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature