Coefficient of Variation in Metastatic Lymph Nodes Determined by ¹⁸F-FDG PET/CT in Patients with Advanced NSCLC: Combination with Coefficient of Variation in Primary Tumors.

ABSTRACT: Purpose The aim of the present study was to test whether the coefficient of variation (CoV) of ¹⁸F-FDG PET/CT images of metastatic lymph nodes and primary tumors may predict clinical outcome in patients with advanced non-small cell lung cancer (NSCLC). Materials and Methods Fifty-eight NSCLC patients who had undergone ¹⁸F-FDG PET/CT at diagnosis were evaluated. SUVmax, SUVmean, CoV, MTV and TLG were determined in targeted lymph nodes and corresponding primary tumors along with Total MTV (MTV_TOT) and Whole-Body TLG (TLG_WB) of all malignant lesions. Univariate analysis was performed using Cox proportional hazards regression whereas the Kaplan-Meier method and log-rank tests were used for survival analysis. Results Fifty-eight metastatic lymph nodes

SUBMITTER: Pellegrino S 

PROVIDER: S-EPMC10813913 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature