Adoption of Total Neoadjuvant Therapy in the Treatment of Locally Advanced Rectal Cancer.

ABSTRACT: Local and metastatic recurrence are primary concerns following the treatment of locally advanced rectal cancer (LARC). Chemoradiation (CRT) can reduce the local recurrence rates and has subsequently moved to the neoadjuvant setting from the adjuvant setting. Pathological complete response (pCR) rates have also been noted to be greater in patients treated with neoadjuvant CRT prior to surgery. The standard approach to treating LARC would often involve CRT followed by surgery and optional adjuvant chemotherapy and remained the treatment paradigm for almost two decades. However, patients were often unable to complete adjuvant chemotherapy due to a decreased tolerance of chemotherapy following surgery, which led to upfront treatment with both CRT and chemotherapy, and total neoadjuvant therapy

SUBMITTER: Conces ML 

PROVIDER: S-EPMC10813931 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature