Towards Understanding the Development of Breast Cancer: The Role of RhoJ in the Obesity Microenvironment.

ABSTRACT: Obesity is a growing pandemic with an increasing risk of inducing different cancer types, including breast cancer. Adipose tissue is proposed to be a major player in the initiation and progression of breast cancer in obese people. However, the mechanistic link between adipogenicity and tumorigenicity in breast tissues is poorly understood. We used in vitro and in vivo approaches to investigate the mechanistic relationship between obesity and the onset and progression of breast cancer. In obesity, adipose tissue expansion and remodeling are associated with increased inflammatory mediator's release and anti-inflammatory mediators' reduction.. In order to mimic the obesity micro-environment, we cultured cells in an enriched pro-inflammatory cytokine medium to which we added a low concentratio

SUBMITTER: Bou Malhab LJ 

PROVIDER: S-EPMC10814036 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature