Relevance of <i>HOTAIR</i> rs920778 and rs12826786 Genetic Variants in Bladder Cancer Risk and Survival.

ABSTRACT: The long non-coding RNA HOX transcript antisense intergenic RNA (HOTAIR) is associated with oncogenic features in bladder cancer and is predictive of poor clinical outcomes in patients diagnosed with this disease. In this study, we evaluated the impact of the HOTAIR single nucleotide polymorphisms rs920778 and rs12826786 on bladder cancer risk and survival. This case-control study included 106 bladder cancer patients and 199 cancer-free controls. Polymorphisms were evaluated through PCR-restriction fragment length polymorphism. The odds ratio and 95% confidence intervals were tested using univariable and multivariable logistic regressions. The effects on patient survival were evaluated using the log-rank test and Cox regression models. Our data showed that the HOTAIR r

SUBMITTER: Martins EP 

PROVIDER: S-EPMC10814037 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature