The Genetic Aspects of Periodontitis Pathogenesis and the Regenerative Properties of Stem Cells.

ABSTRACT: Periodontitis (PD) is a prevalent and chronic inflammatory disease with a complex pathogenesis, and it is associated with the presence of specific pathogens, such as Porphyromonas gingivalis. Dysbiosis and dysregulated immune responses ultimately lead to chronic inflammation as well as tooth and alveolar bone loss. Multiple studies have demonstrated that genetic polymorphisms may increase the susceptibility to PD. Furthermore, gene expression is modulated by various epigenetic mechanisms, such as DNA methylation, histone modifications, or the activity of non-coding RNA. These processes can also be induced by PD-associated pathogens. In this review, we try to summarize the genetic processes that are implicated in the pathogenesis of PD. Furthermore, we discuss the use of these mechan

SUBMITTER: Ustianowska K 

PROVIDER: S-EPMC10814055 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature