Advanced Hyperpolarized ¹³C Metabolic Imaging Protocol for Patients with Gliomas: A Comprehensive Multimodal MRI Approach.

ABSTRACT: This study aimed to implement a multimodal ¹H/HP-¹³C imaging protocol to augment the serial monitoring of patients with glioma, while simultaneously pursuing methods for improving the robustness of HP-¹³C metabolic data. A total of 100 ¹H/HP [1-¹³C]-pyruvate MR examinations (104 HP-¹³C datasets) were acquired from 42 patients according to the comprehensive multimodal glioma imaging protocol. Serial data coverage, accuracy of frequency reference, and acquisition delay were evaluated using a mixed-effects model to account for multiple exams per patient. Serial atlas-based HP-¹³C MRI demonstrated consistency in volumetric coverage measured by inter-exam dice coefficients (0.977 ± 0.008, mean ± SD; four patients/11 ex

SUBMITTER: Autry AW 

PROVIDER: S-EPMC10814348 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature