Plasma Cell-Free Tumor Methylome as a Biomarker in Solid Tumors: Biology and Applications.

ABSTRACT: DNA methylation is a fundamental mechanism of epigenetic control in cells and its dysregulation is strongly implicated in cancer development. Cancers possess an extensively hypomethylated genome with focal regions of hypermethylation at CPG islands. Due to the highly conserved nature of cancer-specific methylation, its detection in cell-free DNA in plasma using liquid biopsies constitutes an area of interest in biomarker research. The advent of next-generation sequencing and newer computational technologies have allowed for the development of diagnostic and prognostic biomarkers that utilize methylation profiling to diagnose disease and stratify risk. Methylome-based predictive biomarkers can determine the response to anti-cancer therapy. An additional emerging application of these biomark

SUBMITTER: Sacdalan DB 

PROVIDER: S-EPMC10814449 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature