Detection of Genomic Structural Variations Associated with Drug Sensitivity and Resistance in Acute Leukemia.

ABSTRACT: Acute leukemia is a particularly problematic collection of hematological cancers, and, while somewhat rare, the survival rate of patients is typically abysmal without bone marrow transplantation. Furthermore, traditional chemotherapies used as standard-of-care for patients cause significant side effects. Understanding the evolution of leukemia to identify novel targets and, therefore, drug treatment regimens is a significant medical need. Genomic rearrangements and other structural variations (SVs) have long been known to be causative and pathogenic in multiple types of cancer, including leukemia. These SVs may be involved in cancer initiation, progression, clonal evolution, and drug resistance, and a better understanding of SVs from individual patients may help guide therapeutic options.

SUBMITTER: Finlay D 

PROVIDER: S-EPMC10814465 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature