Sirt6-Mediated Cell Death Associated with Sirt1 Suppression in Gastric Cancer.

ABSTRACT:

Background

Gastric cancer, one of the leading causes of cancer-related death, is strongly associated with H. pylori infection, although other risk factors have been identified. The sirtuin (Sirt) family is involved in the tumorigenesis of gastric cancer, and sirtuins can have pro- or anti-tumorigenic effects.

Methods

After determining the overall survival rate of gastric cancer patients with or without Sirt6 expression, the effect of Sirt6 upregulation was also tested using a xenograft mouse model. The regulation of Sirt6 and Sirt1, leading to the induction of mouse double minute 2 homolog (MDM2) and reactive oxygen species (ROS), was mainly analyzed using Western blotting and immunofluorescence staining, and gastric cancer cell (SNU-638) death associated with these p

SUBMITTER: Seo JH 

PROVIDER: S-EPMC10814469 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature