Electrophoretic patterns of proteinuria in feline spontaneous chronic kidney disease.

ABSTRACT:

Objectives

The purpose of this study was to describe the electrophoretic patterns of proteinuria in cats at risk of and cats with chronic kidney disease (CKD), and to investigate whether the presence of high-molecular-weight (HMW) and low-molecular-weight (LMW) proteins were associated with CKD, proteinuria and/or disease progression.

Methods

Healthy cats at risk of developing renal disease (n = 17) and cats affected with CKD at different stages (n = 22) were prospectively enrolled and sampled over time. Seventy urine samples were included and assayed with a commercially available sodium dodecyl sulfate-agarose gel electrophoresis (SDS-AGE) method. Each sample (gel lane) was inspected to identify albumin, HMW and LMW proteins, and an electrophoretic pattern (albuminuria, glo

SUBMITTER: Giraldi M 

PROVIDER: S-EPMC10814560 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature