In Vitro Anti-Inflammatory Study of Limonoids Isolated from Chisocheton Plants.

ABSTRACT: Chisocheton plants from the family Meliaceae have traditionally been used to treat several diseases; however, scientific evidence is limited. The most abundant chemical constituents of this plant are the limonoids, which are known for their various biological activities, including anti-inflammatory effects. However, the anti-inflammatory effects and underlying mechanisms of action of the constituents of Chisocheton plants have not been fully explored. In this report, we evaluated the anti-inflammatory activity of 17 limonoid compounds from Chisocheton plant primarily by measuring their inhibitory effects on the production of pro-inflammatory cytokines, including TNF-α, IL-6, IL-1β, and MCP-1, in LPS-stimulated THP-1 cells using an ELISA assay. Compounds 3, 5<

SUBMITTER: Hilmayanti E 

PROVIDER: S-EPMC10814725 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature