Deficiency of Stabilin-1 in the Context of Hepatic Melanoma Metastasis.

ABSTRACT:

Background

This study analyzed the role of Stabilin-1 on hepatic melanoma metastasis in preclinical mouse models.

Methods

In Stabilin-1^-/- mice (Stab1 KO), liver colonization of B16F10 luc2 and Wt31 melanoma was investigated. The numbers, morphology, and vascularization of hepatic metastases and the hepatic microenvironment were analyzed by immunofluorescence.

Results

While hepatic metastasis of B16F10 luc2 or Wt31 melanoma was unaltered between Stab1 KO and wildtype (Ctrl) mice, metastases of B16F10 luc2 tended to be smaller in Stab1 KO. The endothelial differentiation of both types of liver metastases was similar in Stab1 KO and Ctrl. No differences in initial tumor cell adhesion and retention to the liver vasculature were dete

SUBMITTER: Wohlfeil SA 

PROVIDER: S-EPMC10814973 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature