Combined Merkel Cell Carcinoma and Squamous Cell Carcinoma: A Systematic Review.

ABSTRACT: Combined Merkel cell carcinoma (MCC) and squamous cell carcinoma (SCC) have classically been regarded as more aggressive than conventional, pure, Merkel cell polyomavirus (MCPyV)-positive MCC. It is still unknown whether combined MCC and SCC are more aggressive than pure, MCPyV-negative MCC, and the origin of both the SCC and MCC elements of these combined tumors has not been elucidated. The main objective of this systematic review was to assess whether combined MCC and SCC tumors are associated with a worse prognosis than pure MCC; the secondary goals were the characterization of the clinical and histopathological features of these combined neoplasms. A total of 38 studies, including 152 patients, were selected for review. In total, 76% of the cases were MCPyV-negative, whereas 4% were MC

SUBMITTER: Rios-Vinuela E 

PROVIDER: S-EPMC10814983 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature