Suitability of Ex Vivo-Expanded Microtic Perichondrocytes for Auricular Reconstruction.

ABSTRACT: Tissue engineering (TE) techniques offer solutions for tissue regeneration but require large quantities of cells. For microtia patients, TE methods represent a unique opportunity for therapies with low donor-site morbidity and reliance on the surgeon's individual expertise. Microtia-derived chondrocytes and perichondrocytes are considered a valuable cell source for autologous reconstruction of the pinna. The aim of this study was to investigate the suitability of perichondrocytes from microtia patients for autologous reconstruction in comparison to healthy perichondrocytes and microtia chondrocytes. Perichondrocytes were isolated via two different methods: explant culture and enzymatic digestion. The isolated cells were analyzed in vitro for their chondrogenic cell properties. We examined

SUBMITTER: Jakob Y 

PROVIDER: S-EPMC10814984 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature