Cortistatin as a Novel Multimodal Therapy for the Treatment of Parkinson's Disease.

ABSTRACT: Parkinson's disease (PD) is a complex disorder characterized by the impairment of the dopaminergic nigrostriatal system. PD has duplicated its global burden in the last few years, becoming the leading neurological disability worldwide. Therefore, there is an urgent need to develop innovative approaches that target multifactorial underlying causes to potentially prevent or limit disease progression. Accumulating evidence suggests that neuroinflammatory responses may play a pivotal role in the neurodegenerative processes that occur during the development of PD. Cortistatin is a neuropeptide that has shown potent anti-inflammatory and immunoregulatory effects in preclinical models of autoimmune and neuroinflammatory disorders. The goal of this study was to explore the therapeutic potential of

SUBMITTER: Serrano-Martinez I 

PROVIDER: S-EPMC10815070 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature