Enhancing Human Cutaneous Wound Healing through Targeted Suppression of Large Conductance Ca²⁺-Activated K⁺ Channels.

ABSTRACT: The modulation of K⁺ channels plays a crucial role in cell migration and proliferation, but the effect of K⁺ channels on human cutaneous wound healing (CWH) remains underexplored. This study aimed to determine the necessity of modulating K⁺ channel activity and expression for human CWH. The use of 25 mM KCl as a K⁺ channel blocker markedly improved wound healing in vitro (in keratinocytes and fibroblasts) and in vivo (in rat and porcine models). K⁺ channel blockers, such as quinine and tetraethylammonium, aided in vitro wound healing, while Ba²⁺ was the exception and did not show similar effects. Single-channel recordings revealed that the Ba²⁺-insensitive large conductance Ca²⁺-activated K⁺

SUBMITTER: Choi CR 

PROVIDER: S-EPMC10815220 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature