Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis.

ABSTRACT: Sepsis ranks among the most common health problems worldwide, characterized by organ dysfunction resulting from infection. Excessive inflammatory responses, cytokine storms, and immune-induced microthrombosis are pivotal factors influencing the progression of sepsis. Our objective was to identify novel immune-related hub genes for sepsis through bioinformatic analysis, subsequently validating their specificity and potential as diagnostic and prognostic biomarkers in an animal experiment involving a sepsis mice model. Gene expression profiles of healthy controls and patients with sepsis were obtained from the Gene Expression Omnibus (GEO) and analysis of differentially expressed genes (DEGs) was conducted. Subsequently, weighted gene co-expression network analysis (WGCNA) was used to analyz

SUBMITTER: Li N 

PROVIDER: S-EPMC10815248 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature