The Pupa Stage Is the Most Sensitive to Hypoxia in Drosophila melanogaster.

ABSTRACT: Hypoxia not only plays a critical role in multiple disease conditions; it also influences the growth and development of cells, tissues and organs. To identify novel hypoxia-related mechanisms involved in cell and tissue growth, studying a precise hypoxia-sensitive time window can be an effective approach. Drosophila melanogaster has been a useful model organism for studying a variety of conditions, and we focused in this study on the life cycle stages of Drosophila to investigate their hypoxia sensitivity. When normoxia-grown flies were treated with 4% O₂ at the pupa stage for 3, 2 and 1 day/s, the eclosion rates were 6.1%, 66.7% and 96.4%, respectively, and, when 4% O₂ was kept for the whole pupa stage, this regimen was lethal. Surprisingly, when our hy

SUBMITTER: Stobdan T 

PROVIDER: S-EPMC10815303 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature