Pathophysiology of Atrial Fibrillation and Approach to Therapy in Subjects Less than 60 Years Old.

ABSTRACT: Atrial fibrillation (AF) is an arrhythmia that affects the left atrium, cardiac function, and the patients' survival rate. Due to empowered diagnostics, it has become increasingly recognized among young individuals as well, in whom it is influenced by a complex interplay of autoimmune, inflammatory, and electrophysiological mechanisms. Deepening our understanding of these mechanisms could contribute to improving AF management and treatment. Inflammation is a complexly regulated process, with interactions among various immune cell types, signaling molecules, and complement components. Addressing circulating antibodies and designing specific autoantibodies are promising therapeutic options. In cardiomyopathies or channelopathies, the first manifestation could be paroxysmal AF; persistent for

SUBMITTER: Curcio A 

PROVIDER: S-EPMC10815447 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature