Expression of Elafin and CD200 as Immune Checkpoint Molecules Involved in Celiac Disease.

ABSTRACT: We comprehensively evaluated the expression of therapeutically targetable immune checkpoint molecules involved in celiac disease (CD). We have focused on the alteration of the CD200/CD200R pathway and Elafin expression in celiac disease and discussed their roles in regulating the immune response. There are limited data related to the expression or function of these molecules in celiac disease. This finding could significantly contribute to the understanding of the clinical manifestation of CD. CD200, CD200R and Elafin distributions were determined by ELISA and immunohistochemistry analyses in serum and biopsies of CD patients. Analyses of Th1 and Th17 cytokines were determined. PCR amplification of a fragment of the PI3 gene was carried out using genomic DNA isolated from whole bloo

SUBMITTER: Ponce-de-Leon C 

PROVIDER: S-EPMC10815464 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature