Potential Role of Macrophage Polarization in the Progression of Hunner-Type Interstitial Cystitis.

ABSTRACT:

Background

Hunner-type interstitial cystitis (HIC) is a chronic inflammatory condition of the bladder. However, it remains unclear whether there is a causal relationship between the presence of Hunner lesions and seemingly normal-appearing areas in the bladder (non-Hunner lesions). This study aimed to investigate the fundamental aspects of HIC by examining potential genetic differences between Hunner and non-Hunner lesions and elucidate their role as potential markers in the progression and suppression of the disease.

Methods

This cross-sectional study enrolled patients with HIC (n = 10) who underwent supratrigonal cystectomy along with augmentation cystoplasty. Full-thickness bladder tissue was collected from Hunner and non-Hunner lesions in the same patient. Normal

SUBMITTER: Ko KJ 

PROVIDER: S-EPMC10815545 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature