Comparative Analysis of Transcriptome Profiles in Patients with Thromboangiitis Obliterans.

ABSTRACT:

Background

Thromboangiitis obliterans (TAO) causes vascular insufficiency due to chronic inflammation and abrupt thrombosis of the medium and small arteries of the extremities. In our study, we aimed to determine biomarkers for the diagnosis of TAO by evaluating 15 male TAO patients with Shinoya diagnostic criteria and 5 healthy controls who did not have TAO-related symptoms in their family histories.

Methods

The Clariom D Affymetrix platform was used to conduct microarray analysis on total RNA extracted from whole blood. A total of 477 genes (FC ≤ 5 or >5) common to the fifteen patient and five control samples were selected using comparative microarray analysis; among them, 79 genes were upregulated and 398 genes were downregulated.

Results

According to FC ≤ 10 or >1

SUBMITTER: Oztan G 

PROVIDER: S-EPMC10815726 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature