Aptamer-Based Recognition of Breast Tumor Cells: A New Era for Breast Cancer Diagnosis.

ABSTRACT: Breast cancer is one of the leading causes of death among women worldwide and can be classified into four major distinct molecular subtypes based on the expression of specific receptors. Despite significant advances, the lack of biomarkers for detailed diagnosis and prognosis remains a major challenge in the field of oncology. This study aimed to identify short single-stranded oligonucleotides known as aptamers to improve breast cancer diagnosis. The Cell-SELEX technique was used to select aptamers specific to the MDA-MB-231 tumor cell line. After selection, five aptamers demonstrated specific recognition for tumor breast cell lines and no binding to non-tumor breast cells. Validation of aptamer specificity revealed recognition of primary and metastatic tumors of all subtypes. In particula

SUBMITTER: de Araujo NS 

PROVIDER: S-EPMC10815801 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature