Circulating microRNA miR-425-5p Associated with Brain White Matter Lesions and Inflammatory Processes.

ABSTRACT: White matter lesions (WML) emerge as a consequence of vascular injuries in the brain. While they are commonly observed in aging, associations have been established with neurodegenerative and neurological disorders such as dementia or stroke. Despite substantial research efforts, biological mechanisms are incomplete and biomarkers indicating WMLs are lacking. Utilizing data from the population-based Study of Health in Pomerania (SHIP), our objective was to identify plasma-circulating micro-RNAs (miRNAs) associated with WMLs, thus providing a foundation for a comprehensive biological model and further research. In linear regression models, direct association and moderating factors were analyzed. In 648 individuals, we identified hsa-miR-425-5p as directly associated with WMLs.

SUBMITTER: Van der Auwera S 

PROVIDER: S-EPMC10815886 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature