From the Colon to the Liver: How Gut Microbiota May Influence Colorectal Cancer Metastatic Potential.

ABSTRACT: The gut microbiota's influence on human tumorigenesis is a burning topic in medical research. With the new ontological perspective, which considers the human body and its pathophysiological processes as the result of the interaction between its own eukaryotic cells and prokaryotic microorganisms living in different body niches, great interest has arisen in the role of the gut microbiota on carcinogenesis. Indeed, dysbiosis is currently recognized as a cancer-promoting condition, and multiple molecular mechanisms have been described by which the gut microbiota may drive tumor development, especially colorectal cancer (CRC). Metastatic power is undoubtedly one of the most fearsome features of neoplastic tissues. Therefore, understanding the underlying mechanisms is of utmost importance to im

SUBMITTER: Mignini I 

PROVIDER: S-EPMC10815973 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature