Dataset Information

Comparison of Mid-Term Prognosis in Intermediate-to-Low-Risk Contemporary Population with Guidelines-Oriented Age Cutoff.

ABSTRACT:

Background

Current European guidelines support transcatheter aortic valve implantation (TAVI) in intermediate-to-low-risk patients ≥75 years-old, but its prognostic relevance is unknown.

Methods

Intermediate-to-low-risk (The Society of Thoracic Surgeons score <8%) patients enrolled in the HORSE registry were included. We compared the populations aged under 75 with those over 75. The primary endpoint was all-cause mortality.

Results

A total of 2685 patients were included: 280 (8.6%) < 75 and 2405 ≥ 75 years. Through a mean follow-up of 437 ± 381 days, 198 (8.2%) and 23 (8.2%) patients died in the two arms without statistically significant differences (log-rank p = 0.925). At Cox regression analysis, age did not predict the occurrence of all-cause death, neither as a continuous variable (HR 1.01, 95% CI 0.99-1.04, p = 0.294) nor dichotomizing according to the prespecified cutoff of 75 years (HR 0.97, 95% CI 0.63-1.51, p = 0.924). Time-to-event ROC curves showed low accuracy of age to predict all-cause mortality (area under the curve of 0.54 for both 1-year and 2-year outcomes).

Conclusions

TAVI has comparable benefits across age strata for intermediate-to-low-risk patients. The age cutoff suggested by the current guidelines is not predictive of the risk of adverse events during hospital stays or of all-cause mortality through a mid-term follow-up.

SUBMITTER: Benenati S

PROVIDER: S-EPMC10816002 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Publications

Comparison of Mid-Term Prognosis in Intermediate-to-Low-Risk Contemporary Population with Guidelines-Oriented Age Cutoff.

Benenati Stefano S Gallo Francesco F Kim Won-Keun WK Khokhar Arif A AA Zeus Tobias T Toggweiler Stefan S Galea Roberto R De Marco Federico F Mangieri Antonio A Regazzoli Damiano D Reimers Bernhard B Nombela-Franco Luis L Barbanti Marco M Regueiro Ander A Piva Tommaso T Rodes-Cabau Josep J Porto Italo I Colombo Antonio A Giannini Francesco F Sticchi Alessandro A

Journal of cardiovascular development and disease 20240122 1

<h4>Background</h4>Current European guidelines support transcatheter aortic valve implantation (TAVI) in intermediate-to-low-risk patients ≥75 years-old, but its prognostic relevance is unknown.<h4>Methods</h4>Intermediate-to-low-risk (The Society of Thoracic Surgeons score <8%) patients enrolled in the HORSE registry were included. We compared the populations aged under 75 with those over 75. The primary endpoint was all-cause mortality.<h4>Results</h4>A total of 2685 patients were included: 28 ...[more]

PMID: 38276659

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Dataset Information

Comparison of Mid-Term Prognosis in Intermediate-to-Low-Risk Contemporary Population with Guidelines-Oriented Age Cutoff.

Background

Methods

Results

Conclusions

Publications

Comparison of Mid-Term Prognosis in Intermediate-to-Low-Risk Contemporary Population with Guidelines-Oriented Age Cutoff.

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