BMP9-ID1 Pathway Attenuates N⁶-Methyladenosine Levels of CyclinD1 to Promote Cell Proliferation in Hepatocellular Carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) is a highly lethal malignant neoplasm, and the involvement of bone morphogenetic protein 9 (BMP9) has been implicated in the pathogenesis of liver diseases and HCC. Our goal was to investigate the role of BMP9 signaling in regulating N6-methyladenosine (m⁶A) methylation and cell cycle progression, and evaluate the therapeutic potential of BMP receptor inhibitors for HCC treatment. We observed that elevated levels of BMP9 expression in tumor tissues or serum samples from HCC patients were associated with a poorer prognosis. Through in vitro experiments utilizing the m⁶A dot blotting assay, we ascertained that BMP9 reduced the global RNA m⁶A methylation level in Huh7 and Hep3B cells, thereby facilitating their cell cycle progres

SUBMITTER: Chen H 

PROVIDER: S-EPMC10816017 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature