Enhanced Sensitivity of A549 Cells to Doxorubicin with WS₂ and WSe₂ Nanosheets via the Induction of Autophagy.

ABSTRACT: The excellent physicochemical properties of two-dimensional transition-metal dichalcogenides (2D TMDCs) such as WS₂ and WSe₂ provide potential benefits for biomedical applications, such as drug delivery, photothermal therapy, and bioimaging. WS₂ and WSe₂ have recently been used as chemosensitizers; however, the detailed molecular basis underlying WS₂- and WSe₂-induced sensitization remains elusive. Our recent findings showed that 2D TMDCs with different thicknesses and different element compositions induced autophagy in normal human bronchial epithelial cells and mouse alveolar macrophages at sublethal concentrations. Here, we explored the mechanism by which WS₂ and WSe₂ act as sensitizers to increase l

SUBMITTER: Jin W 

PROVIDER: S-EPMC10816038 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature