Association between Type 1 Diabetes Mellitus and Parkinson's Disease: A Mendelian Randomization Study.

ABSTRACT: While much evidence suggests that type 2 diabetes mellitus increases the risk of Parkinson's disease (PD), the relationship between type 1 diabetes mellitus (T1DM) and PD is unclear. To study their association, we performed a two-sample Mendelian randomization (MR) using the following statistical methods: inverse variance weighting (IVW), MR-Egger, weight median, and weighted mode. Independent datasets with no sample overlap were retrieved from the IEU GWAS platform. All the MR methods found a lower risk of PD in T1DM (IVW-OR 0.93, 95% CI 0.91-0.96, p = 3.12 × 10^-5; MR-Egger-OR 0.93, 95% CI 0.88-0.98, p = 1.45 × 10^-2; weighted median-OR 0.93, 95% CI 0.89-0.98, p = 2.76 × 10^-3; and weighted mode-OR 0.94, 95% CI 0.9-0.98, p = 1.58

SUBMITTER: Mai AS 

PROVIDER: S-EPMC10816052 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature