Apolar Extracts of St. John's Wort Alleviate the Effects of β-Amyloid Toxicity in Early Alzheimer's Disease.

ABSTRACT: Hypericum perforatum (St. John's wort) has been described to be beneficial for the treatment of Alzheimer's disease (AD). Different extractions have demonstrated efficiency in mice and humans, esp. extracts with a low hypericin and hyperforin content to reduce side effects such as phototoxicity. In order to systematically elucidate the therapeutic effects of H. perforatum extracts with different polarities, APP-transgenic mice were treated with a total ethanol extract (TE), a polar extract obtained from TE, and an apolar supercritical CO₂ (scCO₂) extract. The scCO₂ extract was formulated with silicon dioxide (SiO₂) for better oral application. APP-transgenic mice were treated with several extracts (total, polar, apolar) at different

SUBMITTER: El Menuawy A 

PROVIDER: S-EPMC10816143 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature