Bronchial Progenitor Cells in Obstructive and Neoplastic Lung Disease: A Pilot Study.

ABSTRACT: The alteration of progenitor/stem cells present in the airway epithelium has been observed in patients with COPD. Smoking exposure induces remodeling patterns in bronchial progenitor cells (BPCs), encompassing squamous metaplasia, hyperplasia of basal and of mucus-secreting cells, and the depletion of ciliated and non-mucous secretory cells. Our aim was to assess the expression of p63 and vimentin as potential markers of airway remodeling and the regulation of stem cell populations in obstructive and neoplastic lung disease patients. A retrospective single-center observational study was conducted, including patients undergoing bronchoscopy with bronchial biopsies for suspected lung cancer. p63 and vimentin expression were evaluated via immunohistochemical analysis. There were 25 patients,

SUBMITTER: Ragnoli B 

PROVIDER: S-EPMC10816161 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature