Radiosynthesis and Bioevaluation of ^99mTc-Labeled Isocyanide Ubiquicidin 29-41 Derivatives as Potential Agents for Bacterial Infection Imaging.

ABSTRACT: To develop a novel ^99mTc-labeled ubiquicidin 29-41 derivative for bacterial infection single-photon emission computed tomography (SPECT) imaging with improved target-to-nontarget ratio and lower nontarget organ uptake, a series of isocyanide ubiquicidin 29-41 derivatives (CNnUBI 29-41, n = 5-9) with different carbon linkers were designed, synthesized and radiolabeled with the [^99mTc]Tc(I)⁺ core, [^99mTc][Tc(I)(CO)₃(H₂O)₃]⁺ core and [^99mTc][Tc(V)N]²⁺ core. All the complexes are hydrophilic, maintain good stability and specifically bind Staphylococcus aureus in vitro. The biodistribution in mice with bacterial infection and sterile inflammation demonstrated that [⁹⁹

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC10816394 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature