Pancreatic Neuroendocrine Tumors: Signaling Pathways and Epigenetic Regulation.

ABSTRACT: Pancreatic neuroendocrine tumors (PNETs) are characterized by dysregulated signaling pathways that are crucial for tumor formation and progression. The efficacy of traditional therapies is limited, particularly in the treatment of PNETs at an advanced stage. Epigenetic alterations profoundly impact the activity of signaling pathways in cancer development, offering potential opportunities for drug development. There is currently a lack of extensive research on epigenetic regulation in PNETs. To fill this gap, we first summarize major signaling events that are involved in PNET development. Then, we discuss the epigenetic regulation of these signaling pathways in the context of both PNETs and commonly occurring-and therefore more extensively studied-malignancies. Finally, we will offer a pers

SUBMITTER: Saleh Z 

PROVIDER: S-EPMC10816436 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature