Development of a Nanoparticle System for Controlled Release in Bioprinted Respiratory Scaffolds.

ABSTRACT: The use of nanoparticle systems for the controlled release of growth factors is a promising approach to mimicking of the biochemical environment of native tissues in tissue engineering. However, sustaining growth factor release inside an appropriate therapeutic window is a challenge, particularly in bioprinted scaffolds. In this study, a chitosan-coated alginate-based nanoparticle system loaded with hepatocyte growth factor was developed and then incorporated into bioprinted scaffolds. The release kinetics were investigated with a focus on identifying the impact of the chitosan coating and culture conditions. Our results demonstrated that the chitosan coating decreased the release rate and lessened the initial burst release, while culturing in dynamic conditions had no significant impact c

SUBMITTER: Zimmerling A 

PROVIDER: S-EPMC10816437 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature