Exploring the Hemostatic Effects of Platelet Lysate-Derived Vesicles: Insights from Mouse Models.

ABSTRACT: Platelet transfusion has various challenges, and platelet-derived extracellular vesicles have been reported to have more significant procoagulant activity than platelets themselves. Furthermore, platelet products derived from platelet-rich plasma and platelet lysates (PLs) have gained attention for their physiological activity and potential role as drug delivery vehicles owing to the properties of their membranes. We aimed to investigate the characteristics of the fractions isolated through ultracentrifugation from mouse-washed PLs and assess the potential clinical applications of these fractions as a therapeutic approach for bleeding conditions. We prepared PLs from C57BL/6 mouse-washed platelets and isolated three different fractions (20K-vesicles, 100K-vesicles, and PLwo-vesicles) using

SUBMITTER: Hirayu N 

PROVIDER: S-EPMC10816445 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature