Magnesium and Vascular Calcification in Chronic Kidney Disease: Current Insights.

ABSTRACT: Magnesium (Mg) plays crucial roles in multiple essential biological processes. As the kidneys are the primary organ responsible for maintaining the blood concentration of Mg, people with chronic kidney disease (CKD) may develop disturbances in Mg. While both hyper- and hypomagnesemia may lead to adverse effects, the consequences associated with hypomagnesemia are often more severe and lasting. Importantly, observational studies have shown that CKD patients with hypomagnesemia have greater vascular calcification. Vascular calcification is accelerated and contributes to a high mortality rate in the CKD population. Both in vitro and animal studies have demonstrated that Mg protects against vascular calcification via several potential mechanisms, such as inhibiting the formation of both hydrox

SUBMITTER: Zaslow SJ 

PROVIDER: S-EPMC10816532 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature