Quantitative association between gene expression and blood cell production of individual hematopoietic stem cells in mice.

ABSTRACT: Individual hematopoietic stem cells (HSCs) produce different amounts of blood cells upon transplantation. Taking advantage of the intercellular variation, we developed an experimental and bioinformatic approach to evaluating the quantitative association between gene expression and blood cell production across individual HSCs. We found that most genes associated with blood production exhibit the association only at some levels of blood production. By mapping gene expression with blood production, we identified four distinct patterns of their quantitative association. Some genes consistently correlate with blood production over a range of levels or across all levels, and these genes are found to regulate lymphoid but not myeloid production. Other genes exhibit one or more clear peaks of asso

SUBMITTER: Jiang D 

PROVIDER: S-EPMC10816716 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature