Strong Sex-Dependent Effects of Malnutrition on Life- and Healthspan in Drosophila melanogaster.

ABSTRACT: Insufficient intake of essential nutrients, malnutrition is a major issue for millions of people and has a strong impact on the distribution and abundance of species in nature. In this study, we investigated the effect of malnutrition on several fitness components in the vinegar fly Drosophila melanogaster. Four diets with different nutritional values, including three diluted diets of an optimal nutritional balanced diet, were used as feed sources. The effect of malnutrition on fitness components linked to healthspan, the period of life spent in good health conditions, was evaluated by quantifying the flies' lifespan, locomotor activity, heat stress tolerance, lipid content, and dry weight. The results showed that malnutrition had severe negative impact, such as reduced lifespan, lo

SUBMITTER: Bak NK 

PROVIDER: S-EPMC10816799 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature