Exploitation of Autophagy Inducers in the Management of Dementia: A Systematic Review.

ABSTRACT: The social burden of dementia is remarkable since it affects some 57.4 million people all over the world. Impairment of autophagy in age-related diseases, such as dementia, deserves deep investigation for the detection of novel disease-modifying approaches. Several drugs belonging to different classes were suggested to be effective in managing Alzheimer's disease (AD) by means of autophagy induction. Useful autophagy inducers in AD should be endowed with a direct, measurable effect on autophagy, have a safe tolerability profile, and have the capability to cross the blood-brain barrier, at least with poor penetration. According to the PRISMA 2020 recommendations, we propose here a systematic review to appraise the measurable effectiveness of autophagy inducers in the improvement of cognitiv

SUBMITTER: Corasaniti MT 

PROVIDER: S-EPMC10816917 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature