Histidine transport is essential for the growth of Staphylococcus aureus at low pH.

ABSTRACT: Staphylococcus aureus is an opportunistic pathogen capable of causing many different human diseases. During colonization and infection, S. aureus will encounter a range of hostile environments, including acidic conditions such as those found on the skin and within macrophages. However, little is known about the mechanisms that S. aureus uses to detect and respond to low pH. Here, we employed a transposon sequencing approach to determine on a genome-wide level the genes required or detrimental for growth at low pH. We identified 31 genes that were essential for the growth of S. aureus at pH 4.5 and confirmed the importance of many of them through follow up experiments using mutant strains inactivated for individual genes. Most of the genes identified code for proteins with functions in cell

SUBMITTER: Beetham CM 

PROVIDER: S-EPMC10817146 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature