Three-component contour dynamics model to simulate and analyze amoeboid cell motility in two dimensions.

ABSTRACT: Amoeboid cell motility is relevant in a wide variety of biomedical processes such as wound healing, cancer metastasis, and embryonic morphogenesis. It is characterized by pronounced changes of the cell shape associated with expansions and retractions of the cell membrane, which result in a crawling kind of locomotion. Despite existing computational models of amoeboid motion, the inference of expansion and retraction components of individual cells, the corresponding classification of cells, and the a priori specification of the parameter regime to achieve a specific motility behavior remain challenging open problems. We propose a novel model of the spatio-temporal evolution of two-dimensional cell contours comprising three biophysiologically motivated components: a stochastic term accountin

SUBMITTER: Schindler D 

PROVIDER: S-EPMC10817190 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature