Longitudinal analysis of antibody responses to Plasmodium vivax sporozoite antigens following natural infection.

ABSTRACT:

Background

P. vivax malaria is a major global health burden hindering social and economic development throughout many tropical and sub-tropical countries. Pre-erythrocytic (PE) vaccines emerge as an attractive approach for the control and elimination of malaria infection. Therefore, evaluating the magnitude, longevity and prevalence of naturally acquired IgG antibody responses against PE candidate antigens is useful for vaccine design.

Methodology/principal findings

The antigenicity of five recombinant PE antigens (PvCSP-VK210, PvSSP3, PvM2-MAEBL, PvCelTOS and PvSPECT1) was evaluated in plasma samples from individuals residing in low transmission areas in Thailand (Ranong and Chumphon Provinces). The samples were collected at the time of acute vivax malaria and 90, 270 and 3

SUBMITTER: Thawornpan P 

PROVIDER: S-EPMC10817200 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature