ATG7/GAPLINC/IRF3 axis plays a critical role in regulating pathogenesis of influenza A virus.

ABSTRACT: Autophagy-related protein 7 (ATG7) is an essential autophagy effector enzyme. Although it is well known that autophagy plays crucial roles in the infections with various viruses including influenza A virus (IAV), function and underlying mechanism of ATG7 in infection and pathogenesis of IAV remain poorly understood. Here, in vitro studies showed that ATG7 had profound effects on replication of IAV. Depletion of ATG7 markedly attenuated the replication of IAV, whereas overexpression of ATG7 facilitated the viral replication. ATG7 conditional knockout mice were further employed and exhibited significantly resistant to viral infections, as evidenced by a lower degree of tissue injury, slower body weight loss, and better survival, than the wild type animals challenged with either IAV (RNA viru

SUBMITTER: Chen B 

PROVIDER: S-EPMC10817227 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature